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چکیده
increase raises a suspicion. Moreover, mean MVD was reported to be 80 in NSCLC using same methodologies [5]. Choosing an evaluation zone in a tumor stroma is another dilemma. Recently, increased tumor islet MCD in NSCLC noticed as favorable. Finally, anti-angiogenic effect of tranilast occurs not by simply MC stabilization rather via its overall inhibiting effect on macrophage cytokine release, fibroblast, and smooth muscle proliferation. Only observing increased MCD in a tumor with bad/good prognosis on pathological specimens seems to be far behind to explain the role of MCs.
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